Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution

Mishra, Rakesh K. ; Latha, P. K. ; Brahmachari, Samir K. (1988) Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution Nucleic Acids Research, 16 (10). pp. 4651-4665. ISSN 0305-1048

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Official URL: http://nar.oxfordjournals.org/content/16/10/4651.s...

Related URL: http://dx.doi.org/10.1093/nar/16.10.4651

Abstract

Oligonucleotides containing alternating purines-pyrimidines with AT base pairs have been shown to exist in the Z-form preferably in solid state. We report that oligodeoxyribonucleotides with GG, TG and CA interruptions in their alternating CG sequences can undergo B to Z transition in solution in the absence of any chemical modification or topological constraint. The sequences, d(CGCGCGGCGCGC) and d(CGTGCGCACG) have been synthesised and shown to adopt Z- conformation in presence of millimolar concentrations of Ni2+ under low water activity conditions. Significance of GG, TG and CA interruptions in the B to Z transition is discussed.

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