Photoinduced DNA strand scission by 1,8-naphthalimide-derived intercalators

Mehrotra, Jyothi ; Misra, K. ; Mishra, Rakesh K. (1992) Photoinduced DNA strand scission by 1,8-naphthalimide-derived intercalators Current Science, 62 (10). pp. 693-695. ISSN 0011-3891

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Abstract

DNA cleavage by non-enzymatic chemical reagents has both basic and applied value. We report here photoinduced strand scission properties of novel DNA intercalators, 4-nitro (N-hexylamine)1,8-naphthalimide. The results indicate that the cleavage takes place via a free-radical mechanism and the efficiency of cleavage is unaltered over a long range pf pH and ionic strength. These intercalators, therefore, provide a probe for studying DNA conformation, conformational micro-heterogeneity, DNA-ligand interactions and have potential use in genome targeting.

Item Type:Article
Source:Copyright of this article belongs to Current Science Association.
ID Code:97051
Deposited On:22 Jan 2013 06:57
Last Modified:19 May 2016 09:16

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