Sharma, Preeti ; Singh, Sangeeta ; Siddiqui, Tanveer I. ; Singh, Vishnu S. ; Kundu, Bijoy ; Prathipati, Philip ; Saxena, Anil K. ; Dikshit, Dinesh K. ; Rastogi, Leena ; Dixit, Chetna ; Gupta, M. B. ; Patnaik, G. K. ; Dikshit, Madhu (2007) α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents European Journal of Medicinal Chemistry, 42 (3). pp. 386-393. ISSN 0223-5234
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S02235...
Related URL: http://dx.doi.org/10.1016/j.ejmech.2006.08.016
Abstract
In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of α-amino acids were screened for their in vitro H+/K+ ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Amino Acids; Pylorus Ligation; H+/K+ ATPase; Anti-ulcer |
| ID Code: | 9685 |
| Deposited On: | 02 Nov 2010 11:01 |
| Last Modified: | 09 Feb 2011 04:33 |
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