Rastogi, R. ; Sharma, S. ; Anand, N. ; Dutta, A. ; Fatma, N. ; Chatterjee, R. K. ; Sen, A. B. (1984) Studies of potential filaricides: part 14--activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis Journal of Helminthology, 58 (3). pp. 251-254. ISSN 0022-149X
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Official URL: http://journals.cambridge.org/action/displayAbstra...
Related URL: http://dx.doi.org/10.1017/S0022149X00027085
Abstract
The synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against Litomosoides carinii in Sigmodon hispidus and Dipetalonema viteae in Mastomys natalensis is reported. At an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult L. carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed chemoprophylactic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Cambridge University Press. |
| ID Code: | 96848 |
| Deposited On: | 11 Feb 2013 06:30 |
| Last Modified: | 11 Feb 2013 06:30 |
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