Effect of pulmonary thromboembolism on circulating neutrophils in mice

Dikshit, M. ; Kumari, R. ; Srimal, R. C. (1992) Effect of pulmonary thromboembolism on circulating neutrophils in mice Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 66 (2-3). pp. 133-139. ISSN 0049-3848

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004938...

Related URL: http://dx.doi.org/10.1016/0049-3848(92)90183-B


The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), O2 radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myeloperoxidase (MPO) and lysozyme were estimated in lysed neutrophil preparations. Activities of SOD and CAT were increased in neutrophils, while animals showed 60± 4% thrombocytopenia. Levels of MDA in PMNLs were also elevated significantly following thrombosis. However, there was no significant change in superoxide radical generation, after thrombotic challenge, in mice neutrophils. The present study provides evidence for the involvement of free radicals in mice pulmonary thromboembolism.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Thrombosis; Neutrophils; Catalase; Superoxide Dismutase; Malonaldehyde; Lysozyme And Myeloperoxidase
ID Code:9677
Deposited On:02 Nov 2010 11:07
Last Modified:30 May 2011 11:36

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