Presence of receptors for antigen and antibody on dengue virus-induced suppressor T cells and their products

Chaturvedi, U. C. ; Srivastava, Nisha ; Mathur, Asha (1988) Presence of receptors for antigen and antibody on dengue virus-induced suppressor T cells and their products Current Science, 57 (13). pp. 691-696. ISSN 0011-3891

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Abstract

Dengue type 2 virus (DV)-induced suppressor pathway consists of a cascade of Ts1 cell and its product SF, Ts2 cell and its product SF2 and the Ts3 cell which mediates antigen-specific suppression of humoral immune response. The present study was undertaken to investigate if the different constituents of this pathway have complementary receptors. It was observed that the suppressor activities of Ts1, SF and Ts3 were abrogated by binding with anti-DV antibody while those of Ts2 and SF2 were abrogated by binding with DV antigen. Thus DV-induced suppressor pathway has a network of idiotype-anti-idiotype-like interactions which maintain the antigen specificity.

Item Type:Article
Source:Copyright of this article belongs to Current Science Association.
ID Code:96765
Deposited On:09 Jan 2013 06:14
Last Modified:19 May 2016 09:11

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