In vitro antiviral activity and preliminary clinical trials of a new adamantane compound

Mathur, A. ; Beare, A. S. ; Reed, S. E. (1973) In vitro antiviral activity and preliminary clinical trials of a new adamantane compound Antimicrob Agents Chemother, 4 (4). pp. 421-426. ISSN 0066-4804

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Official URL: http://aac.asm.org/content/4/4/421.abstract

Related URL: http://dx.doi.org/10.1128/​AAC.4.4.421

Abstract

A compound, 1'-methyl spiro (adamantane-2,3'-pyrrolidine) maleate, chemically related to the antiviral drug amantadine, was tested for activity in vitro against a number of human respiratory viruses. By a variety of techniques, it was shown to be active against a wide range of human and animal influenza A viruses. The effect was, however, variable and ranged from high activity against two 1957 Asian strains to no observable activity against a 1971 strain. Like amantadine, the drug did not inhibit the growth of influenza B viruses. It was also inactive against a number of paramyxoviruses. Unlike amantadine, the drug did inhibit rhinoviruses, but to a lesser extent than myxoviruses. The coronavirus 229E was also sensitive to the action of the drug in vitro. Although an earlier trial in volunteers showed that, when given orally from 2 days before until 5 days after virus challenge, the drug was protective against infection with influenza A/Hong Kong/68 virus, a similar trial in volunteers challenged with rhinoviruses 2 and 9 revealed no useful activity against rhinoviruses in man.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:96755
Deposited On:09 Jan 2013 06:51
Last Modified:09 Jan 2013 06:51

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