Status of antioxidants in brain microvessels of monkey and rat

Shukla, Arti ; Dikshit, Madhu ; Srimal, Rikhab Chand (1995) Status of antioxidants in brain microvessels of monkey and rat Free Radical Research, 22 (4). pp. 303-308. ISSN 1071-5762

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Levels of certain antioxidants namely reduced glutathione (GSH), ascorbic acid (Vit C), a-tocopherol (Vit E) and antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were compared in monkey and rat brain microvessels which constitute the blood-brain barrier (BBB). The BBB of both the species contains appreciable amounts of the antioxidants to protect against oxidative damage. The level of protection in rat seems to be more efficient than monkey since rat microvessels contain higher concentrations of some of the bio-antioxidants. The comparative status of enzymatic and non-enzymatic protective system against oxidation in the brain microvessels has been discussed.

Item Type:Article
Source:Copyright of this article belongs to Informa Healthcare.
Keywords:Brain Microvessels; Monkey; Rat; Antioxidants; Antioxidative Enzymes
ID Code:9661
Deposited On:02 Nov 2010 11:13
Last Modified:09 Feb 2011 08:13

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