Methionine metabolism in pyridoxine deficiency

Krishnaswamy, Kamala (1974) Methionine metabolism in pyridoxine deficiency Annals of Nutrition & Metabolism, 17 (1). pp. 55-63. ISSN 0250-6807

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Methionine metabolism was studied in a group of subjects having clinical signs and symptoms of peripheral neuropathy. Following a load of methionine, these subjects excreted higher amounts of cystathionine, and the ratio of cystathionine/ cysteine sulfinic acid was elevated suggesting a block in the conversion of cystathionine to cysteine sulfinic acid. The load return of methionine as cystathionine was significantly more. These results indicate that the activity of enzyme cystathionase, a pyridoxal-dependant enzyme, is low in pyridoxine deficiency. With pyridoxine therapy, there was a significant improvement in the clinical status, and the biochemical abnormalities were corrected.

Item Type:Article
Source:Copyright of this article belongs to Karger Publisher.
Keywords:Methionine; Peripheral Neuropathy; Pyridoxine; Cystathioninuria; Transaminase
ID Code:96382
Deposited On:14 Dec 2012 11:46
Last Modified:14 Dec 2012 11:46

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