Reduction of urinary mutagen excretion in rats fed garlic

Polasa, K. ; Krishnaswamy, K. (1997) Reduction of urinary mutagen excretion in rats fed garlic Cancer Letters, 114 (1-2). pp. 185-186. ISSN 0304-3835

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Naturally occurring substances of plant origin are known to possess antimutagenic potential. Garlic (Allium sativum) was fed to rats in dried powdered form at 0.1%, 0.5% and 1% concentrations in their diet for 4 weeks. At the end of the experiment benzo[a]pyrene (1 mg/rat) was injected intraperitoneally and 24-h urine was collected from the rats. Urinary mutagens were quantitated by the Salmonella typhimurium assay. There was a significant reduction in the excretion of urinary mutagens by carcinogen-exposed rats fed garlic. Further, there was a stimulation in the activities of liver cytosolic glutathione-S-transferase and liver and lung quinone reductases. The study suggested that the antimutagenic potential of garlic may be mediated through induction of detoxification enzymes in target tissues.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Antimutagenesis; Garlic; Chemoprevention
ID Code:96332
Deposited On:13 Dec 2012 11:09
Last Modified:13 Dec 2012 11:09

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