Recent admixture in an Indian population of African ancestry

Narang, Ankita ; Jha, Pankaj ; Rawat, Vimal ; Mukhopadhayay, Arijit ; Dash, Debasis ; Indian Genome Variation Consortium, ; Basu, Analabha ; Mukerji, Mitali (2011) Recent admixture in an Indian population of African ancestry The American Journal of Human Genetics, 89 (1). pp. 111-120. ISSN 0002-9297

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Official URL: http://www.cell.com/AJHG/retrieve/pii/S00029297110...

Related URL: http://dx.doi.org/10.1016/j.ajhg.2011.06.004

Abstract

Identification and study of genetic variation in recently admixed populations not only provides insight into historical population events but also is a powerful approach for mapping disease loci. We studied a population (OG-W-IP) that is of African-Indian origin and has resided in the western part of India for 500 years; members of this population are believed to be descendants of the Bantu-speaking population of Africa. We have carried out this study by using a set of 18,534 autosomal markers common between Indian, CEPH-HGDP, and HapMap populations. Principal-components analysis clearly revealed that the African-Indian population derives its ancestry from Bantu-speaking west-African as well as Indo-European-speaking north and northwest Indian population(s). STRUCTURE and ADMIXTURE analyses show that, overall, the OG-W-IPs derive 58.7% of their genomic ancestry from their African past and have very little inter-individual ancestry variation (8.4%). The extent of linkage disequilibrium also reveals that the admixture event has been recent. Functional annotation of genes encompassing the ancestry-informative markers that are closer in allele frequency to the Indian ancestral population revealed significant enrichment of biological processes, such as ion-channel activity, and cadherins. We briefly examine the implications of determining the genetic diversity of this population, which could provide opportunities for studies involving admixture mapping.

Item Type:Article
Source:Copyright of this article belongs to American Society of Human Genetics.
ID Code:96208
Deposited On:22 Feb 2013 10:00
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