Mapping human genetic diversity in Asia

Abdulla, M. A. ; Ahmed, I. ; Assawamakin, A. ; Bhak, J. ; Brahmachari, S. K. ; Calacal, G. C. ; Chaurasia, A. ; Chen, C.-H. ; Chen, J. ; Chen, Y.-T. ; et al., ; The HUGO Pan-Asian SNP Consortium, (2009) Mapping human genetic diversity in Asia Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075

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Official URL: http://www.sciencemag.org/content/326/5959/1541.ab...

Related URL: http://dx.doi.org/10.1126/science.1177074

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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Source:Copyright of this article belongs to American Association for the Advancement of Science.
ID Code:96181
Deposited On:22 Feb 2013 10:09
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