Platelet 3H ketanserin binding in migraine

Shukla, R. ; Khanna, V. K. ; Pradeep, S. ; Husain, M. ; Tandon, R. ; Nag, D. ; Dikshit, M. ; Srimal, R. C. ; Seth, P. K. (2001) Platelet 3H ketanserin binding in migraine Cephalalgia, 21 (5). pp. 567-572. ISSN 0333-1024

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Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal number of binding sites (Bmax) determined by Scatchard analysis revealed a significant decrease in Kd and no change in Bmax in migraine cases. No correlation was observed between the Kd and Bmax with the clinical features of migraine. The findings of the present study show that there is a decreased affinity of platelet 5-HT2 receptors in migraine.

Item Type:Article
Source:Copyright of this article belongs to International Headache Society.
Keywords:Platelets; Migraine; 5-HT2 Receptors; 3H Ketanserin Binding; Serotonin
ID Code:9598
Deposited On:02 Nov 2010 11:48
Last Modified:30 May 2011 11:10

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