Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines

Mandal, S. ; Khomutov, M. A. ; Simonian, A. R. ; Kochetkov, S. N. ; Madhubala, R. (2011) Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines Molecular Biology, 45 (4). pp. 619-623. ISSN 0026-8933

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Official URL: http://dx.doi.org/10.1134/S002689331104008X

Related URL: http://dx.doi.org/10.1134/S002689331104008X

Abstract

The ability of α-, ν-, γ- and ω-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated. Only β-methylated spermidine, like natural spermidine, was capable of restoring the growth of L. donovani, while the remaining three analogues turned out to be inactive. α-Methylated spermidine is a functionally active spermidine surrogate both in vivo and in vitro, hence this analogue may be considered as an antidote in the host-parasite system, especially in the cases where inhibitors of polyamine biosynthesis are used for the therapy of leishmaniasis.

Item Type:Article
Source:Copyright of this article belongs to SP MAIK Nauka/Interperiodica.
Keywords:Spermidine; C-Methylated Spermidine Analogues; Leishmaniasis
ID Code:95971
Deposited On:30 Nov 2012 10:16
Last Modified:30 Nov 2012 10:16

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