Arora, Taruna ; Nath, Rhisita ; Vashistha, Nidhi ; Kumari, Nikki ; Hussain, Shah Saddad ; Muralidhar, Kambadur (2012) Mechanistic investigations of the dual activity of Gonadotropins using target tissue cAMP level as a response parameter World Journal of Life Science and Medical Research, 2 (4). pp. 150-158. ISSN 2249-0574
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Official URL: http://www.rrpjournals.com/wjlsmr/WJLSMR%202012;2%...
Abstract
Gonadotropins like human chorionic gonadotropin (hCG) and pregnant mare serum gonadotropin (PMSG) exhibit dual activities on target tissues. The status of cAMP as a second messenger in these activities has been examined experimentally. Direct correlation with target tissue cAMP concentration, has been observed in the case of thyrotropic effect of hCG on thyroid tissue and the ovarian ascorbic acid depletion effect of hCG on superovulated immature rat ovaries. Marked difference in the response of buffalo tissues in comparison to rat tissues has been observed. No correlation could be observed between cAMP levels and ovarian ascorbic acid content in the case of PMSG action. Surprisingly a peptide derived from buffalo Prolactin appears to have antigonadotropic effect as far as ovarian ascorbic acid content is concerned.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Research, Reviews, Publications. |
| Keywords: | Hormones; Gonadotropins; cAMP; ELISA |
| ID Code: | 95834 |
| Deposited On: | 23 Nov 2012 12:21 |
| Last Modified: | 23 Nov 2012 12:21 |
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