Healing of chronic antral gastritis: effect of sucralfate and colloidal bismuth subcitrate

Kumar, M. ; Yachha, S. K. ; Aggarwal, R. ; Shukla, S. ; Pandey, R. ; Prasad, K. N. ; Ayyagari, A. ; Naik, S. R. (1996) Healing of chronic antral gastritis: effect of sucralfate and colloidal bismuth subcitrate Indian Journal of Gastroenterology, 15 (3). pp. 90-93. ISSN 0254-8860

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Official URL: http://www.indianjgastro.com/IJG_pdf/july1996/90-9...


Background: Colloidal bismuth subcitrate (CBS) causes endoscopic and histological improvement in gastritis and eradication of Helicobacter pylori in patients with non-ulcer dyspepsia (NUD). The effect of sucralfate, a cytoprotective drug, on endoscopic and histologic gastritis and H pylori clearance is not clear. We studied the effect of CBS and sucralfate on these features in patients with NUD. Methods: Sixty three patients with NUD and H pylori infection were randomized to receive one of the following for four weeks: (i) CBS (240 mg twice daily) (Group 1); (ii) placebo I, similar in size, color and shape to CBS (Group 2); (iii) sucralfate (2.0 g twice daily) (Group 3) and (iv) placebo II, similar to sucralfate (Group 4). Symptoms, endoscopic and histological findings and H pylori status were assessed before and after treatment. Results: Similar symptomatic improvement was observed with each treatment, indicating a placebo effect. Significant endoscopic and histological improvement was observed with CBS only. CBS was better than sucralfate in inducing endoscopic and histological improvement. Clearance rate of H pylori was 46.6% with CBS, 16.6% with its placebo, 33.3% with sucralfate and 13.3% with its placebo. Conclusion: CBS is more effective than sucralfate in inducing endoscopic and histologic healing of H pylori-related gastritis among NUD patients.

Item Type:Article
Source:Copyright of this article belongs to Indian Society of Gastroenterology.
Keywords:Bismuth Preparations; Gastric Cytoprotection; Helicobacter Pylori; Non-ulcer Dyspepsia
ID Code:95464
Deposited On:15 Feb 2013 09:10
Last Modified:15 Feb 2013 09:10

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