NF-kB transcription factor: a key player in the generation of immune response

Tripathi, Parul ; Aggarwal, Amita (2006) NF-kB transcription factor: a key player in the generation of immune response Current Science, 90 (4). pp. 519-531. ISSN 0011-3891

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Abstract

Activation of the immune system is a multistep process. The transcription factor nuclear factor-kappa B (NFkB), has been one of the most widely studied molecules in the immune system, as it is activated by a variety of stimuli and it in turn controls diverse genes and biological responses. It is an evolutionarily conserved molecule that coordinates the organism’s response to infection, stress and injury. It plays a major role in the induction of pro-inflammatory genes and affects the various cells involved in immune response as well as affects the generation of innate and adaptive immune response. It is also a target for drugs used in treatment of various inflammatory diseases.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Apoptosis; Inflammatory Diseases; Nuclear Factor-Kappa B; Signal Transduction; Toll-Like Receptors.
ID Code:95185
Deposited On:22 Oct 2012 09:27
Last Modified:19 May 2016 07:52

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