Profile of liver involvement in dengue virus infection

Itha, Srivenu ; Kashyap, Rajesh ; Krishnani, Narendra ; Saraswat, Vivek A. ; Choudhuri, Gourdas ; Aggarwal, Rakesh (2005) Profile of liver involvement in dengue virus infection The National Medical Journal of India, 18 (3). pp. 127-130. ISSN 0970-258X

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Background: Data are scarce on liver involvement in adult patients with dengue virus infection. Methods: During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever. Results: A total of 45 patients with dengue fever (age 7–65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34x109/L (9–99x109). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure. Conclusion: Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease.

Item Type:Article
Source:Copyright of this article belongs to All India Institute of Medical Sciences.
ID Code:94897
Deposited On:16 Oct 2012 08:13
Last Modified:16 Oct 2012 08:13

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