Radiation-induced proctosigmoiditis

Kochhar, R. ; Patel, F. ; Sharma, S. C. ; Ayyagari, S. ; Aggarwal, R. ; Goenka, M. K. ; Gupta, B. D. ; Mehta, S. K. (1991) Radiation-induced proctosigmoiditis Digestive Diseases and Sciences, 36 (1). pp. 103-107. ISSN 0163-2116

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Official URL: http://link.springer.com/article/10.1007%2FBF01300...

Related URL: http://dx.doi.org/10.1007/BF01300096


In a prospective study, 37 consecutive patients with radiation-induced proctosigmoiditis were randomized to receive a four-week course of either 3.0 g oral sulfasalazine plus 20 mg twice daily rectal prednisolone enemas (group I,N=18) or 2.0 g twice daily rectal sucralfate enemas plus oral placebo (group II,N=19). The two groups were comparable with respect to demographic features, duration of symptoms, and clinical and endoscopic staging of the disease. Fifteen patients in group I and 17 in group II completed the trial. At four weeks, both groups showed significant clinical improvement (P<0.01 for group I andP<0.001 for group II) and endoscopic healing (P<0.01 for group I and P<0.001 for group II). When the two groups were compared, sucralfate enemas showed a significantly better response as assessed clinically (P<0.05), although endoscopically the response was not statistically different (P>0.05). We conclude that both treatment regimens are effective in the management of radiation proctitis. Sucralfate enemas give a better clinical response, are tolerated better, and because of the lower cost should be the preferred mode of short-term treatment.

Item Type:Article
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ID Code:94874
Deposited On:17 Oct 2012 10:22
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