Coeliac disease in Indian children: assessment of clinical, nutritional and pathologic characteristics

Mohindra, S. ; Yachha, S. K. ; Srivastava, A. ; Krishnani, N. ; Aggarwal, R. ; Ghoshal, U. C. ; Prasad, K. K. ; Naik, S. R. (2001) Coeliac disease in Indian children: assessment of clinical, nutritional and pathologic characteristics Journal of Health, Population and Nutrition, 19 (3). pp. 204-208. ISSN 1606-0997

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Coeliac disease is an important cause of chronic diarrhoea, failure to thrive, and anaemia in children. Little information on the disease is available in India. This study was undertaken to determine the prevalence, clinical, anthropometric and histological profiles of coeliac disease in patients attending a tertiary referral centre in India. Coeliac disease was diagnosed in 42 (16.6%) of 246 children with chronic diarrhoea, failure to thrive, and anaemia. The mean ages at onset of symptoms and at diagnosis were 2.4 (range 0.5-10) years and 8.3 (range 3-14) years respectively, and a mean period of delay in diagnosis was 5.9 (range 1-13.5) years. Of the 42 cases, history of failure to thrive was observed in 38 (90%), chronic diarrhoea in 37 (88%), and anaemia in 6 cases. Short stature, under-nutrition, anaemia, oedema of feet, rickets, clubbing of fingers, features of vitamin A deficiency, and B-vitamin deficiency were found in 42, 26, 38, 9, 8, 6, 3, and 2 cases respectively. Onset of symptoms, such as, chronic diarrhoea and failure to thrive, was earlier in children with subtotal villous atrophy than in those with partial villous atrophy (mean±SD; 2.00±1.46 years vs 3.30±2.72 years;p<0.05). Results of the study suggest that coeliac disease is not uncommon in Indian children. Coeliac disease should be considered in the differential diagnosis, particularly in children without any symptoms of diarrhoea.

Item Type:Article
Source:Copyright of this article belongs to International Centre for Diarrhoeal Disease Research, Bangladesh
Keywords:Coeliac Disease; Diarrhoea; Diarrhoea, Infantile; Anaemia; Infant Growth; Child Growth; India
ID Code:94774
Deposited On:01 Oct 2013 10:21
Last Modified:01 Oct 2013 10:21

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