Platelet function studies in Indian kala-azar

Dube, B. ; Arora, A. ; Singh, V. P. ; Kumar, K. ; Sundar, S. (1995) Platelet function studies in Indian kala-azar Journal of Tropical Medicine & Hygiene, 98 (3). pp. 166-168. ISSN 0022-5304

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Platelet function studies were conducted on 25 parasitologically positive cases of Indian kala-azar and 25 age and sex matched healthy controls. Ninety-two per cent of patients had thrombocytopenia of variable degree; in 44% of patients, platelets were less than 60,000 mm-3. The platelet adhesive index was less than 30% in 70% of patients with kala-azar (normal 31-60%). Platelet aggregation time with ADP and adrenaline was abnormally prolonged compared to the controls. Platelet factor III availability was poor in 40% of cases. There was a fair degree of correlation between platelet adhesiveness and platelet factor III availability in these patients: 50% of patients with poor platelet adhesiveness showed reduced platelet factor III availability.

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Deposited On:18 Oct 2012 05:05
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