Kumar, Awanish ; Sisodia, Brijesh ; Misra, Pragya ; Sundar, Shyam ; Shasany, Ajit Kumar ; Dube, Anuradha (2010) Proteome mapping of overexpressed membrane-enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani British Journal of Clinical Pharmacology, 70 (4). pp. 609-617. ISSN 0306-5251
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...
Related URL: http://dx.doi.org/10.1111/j.1365-2125.2010.03716.x
Abstract
Over 60% of patients with visceral leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with pentavalent antimonials, the first line of drugs for over 60 years. The drug resistance mechanism, studied so far in in vitro selected laboratory strains, has been attributed to various biochemical parameters. The resistance to Sb (V) in Leishmania field isolates is still unexplored.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | 2-DGE; Leishmania Donovani; MALDI-TOF-MS; Membrane Enriched and Cytosolic Proteins; Promastigotes; Sodium Antimony Gluconate Resistant Clinical Isolate |
| ID Code: | 94514 |
| Deposited On: | 17 Sep 2012 11:35 |
| Last Modified: | 27 Oct 2015 11:36 |
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