Genetic studies in the higher animals: new strategies

Abstract

Recent advances-both conceptual and technical-have enabled the development of novel strategies for correlating phenotype with genotype in the higher animals. Included in these developments are the use of restriction-fragment-Iength polymorphisms (RFLPs) as markers for construction of genetic maps; methods for identifying genes responsible for human inherited disorders in which precise biochemical defects have not yet been ascertained; methods for mapping genes that affect the expression of quantitative (multigenic) traits; and reverse-genetic' approaches to studying the function of cloned genes.