Acetone chemical ionization studies VIII: pyridine derivatives

Vairamani, M. ; Prabhakar, S. ; Raju, Prasada N. ; Rao, Viswanadha G. K. (1995) Acetone chemical ionization studies VIII: pyridine derivatives European Journal of Mass Spectrometry, 1 (6). pp. 539-543. ISSN 1469-0667

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Acetone chemical ionization mass spectra of pyridine and 23 isomeric alkyl, dialkyl, amino, hydroxy, cyano and halo pyridines were studied. The formation of [M + H]+ ions and the adducts corresponding to [M + 43]+ and [M + 59]+ ions is controlled by the proton affinity of the substrate and the position of the substituent. The acetylation reaction is less pronounced in 2-substituted pyridines due to steric factors, except in amino and hydroxypyridines where the acetylated ion is stabilized through hydrogen bonding. Collision-induced dissociation (CID) spectra of [M + 43]+ ions of isomeric amino and hydroxypyridines suggest acetylation occurs mainly at the ring nitrogen.

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ID Code:93838
Deposited On:06 Jul 2012 10:07
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