A calmodulin inhibitor blocks morphogenesis in Candida albicans

Gupta Roy, B. ; Datta, A. (1987) A calmodulin inhibitor blocks morphogenesis in Candida albicans FEMS Microbiology Letters, 41 (3). pp. 327-329. ISSN 0378-1097

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/037810...

Related URL: http://dx.doi.org/10.1111/j.1574-6968.1987.tb02221.x


A calmodulin inhibitor, trifluoperazine (TFP), can block yeast-to-germ-tube morphogenesis of Candida albicans induced by N-acetyl-d-glucosamine at 37°C. Furthermore, the ionophore A23187 can also block germ tube formation, which can be reversed by Ca2+. This indicates the possible involvement of calcium and calmodulin in morphogenesis of C. albicans. During germ tube formation, there is a progressive increase in the rate of protein phosphorylation, which is completely absent in non-germinating cells (yeast form). Trifluoperazine can also inhibit this phosphorylation indicating that protein phosphorylation may also be involved in this process.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Microbiological Societies.
Keywords:Candida Albicans; Morphogenesis; Trifluoperazine
ID Code:9351
Deposited On:02 Nov 2010 12:23
Last Modified:28 May 2011 10:14

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