Development of new amoebicides

Abstract

Amoebiasis is a wide-spread disease with manifold manifestations, the causative organism being Entamoeba histolytica. The sequelae can range from mild stomach upsets to fatal amoebic liver abscess. Development of amoebicides has been facilitated by the elaboration of various animal models for both the invasive and non-invasive varieties of the disease. In this communication drugs discovered thus are briefly mentioned, especially with respect to their mode of action. Reference is also made to the role of plant products in this area.