Interleukin-I inhibits and synthesis of collagen by fibroblast

Bhatnagar, R. ; Penfornis, H. ; Mauviel, A. ; Loyau, G. ; Saklatvala, J. ; Pujol, J. P. (1986) Interleukin-I inhibits and synthesis of collagen by fibroblast Biochemistry International, 13 (4). pp. 709-729. ISSN 0158-5231

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Human dermal fibroblasts, exposed to human or porcine Interleukin-1, responded by an inhibition of collagen synthesis in a dose dependent manner. Incubation with Il-1 for more than 8 h was required to see an appreciable effect. The phenomenon was not dependent on the presence of serum in the culture medium. Since a stimulation of prostaglandin E2 secretion was also observed in presence of Il-1, we investigated the eventual role of arachidonic acid metabolites in the phenomenon. Inhibitors interfering with arachidonate metabolism, namely indomethacin, acetyl salicylic acid, BW 755 C and NDGA had no influence on the inhibition of collagen synthesis caused by Il-1. These data suggest that both cyclooxygenase and lipoxygenase derived metabolites of arachidonic acid are unlikely to play a role in the mechanism.

Item Type:Article
Source:Copyright of this article belongs to International Union of Biochemistry and Molecular Biology.
ID Code:93462
Deposited On:25 Jul 2012 09:00
Last Modified:25 Jul 2012 09:00

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