Synthesis of I-arylpiperazine-4-thiocarboxamides

Nagarajan, K. ; Arya, V. P. ; Venkateswarlu, A. ; Ghate, S. P. (1969) Synthesis of I-arylpiperazine-4-thiocarboxamides Indian Journal of Chemistry, 7 . pp. 1195-1197. ISSN 0019-5103

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The reaction of 1-arylpiperazine salts with hot aqueous ammonium thiocyanate for a short time affords only the thiocyanate salts. l-Arylpiperazine-4-thiocarboxamides have been obtained by prolonged heating of the aqueous solutions of the thiocyanate salts alone or in the presence of acetic acid. Acid or base hydrolysis of l-aryl-4-benzoylthiocarbamoylpiperazines yields the same thiocarboxamides, which are formed also directly by the action of vinylisothiocyanate on 1-arylpiperazines.

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Deposited On:16 Jun 2012 09:13
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