Synthesis & anticonvulsant activity of some condensed imidazoles

Arya, V. P. ; Nagarajan, K. ; David, J. ; Shenoy, S. J. ; Gokhale, N. G. ; Ciba-Geigy, (1978) Synthesis & anticonvulsant activity of some condensed imidazoles Indian Journal of Chemistry, 16B . pp. 226-230. ISSN 0019-5103

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2-Mercapto-4,5-dihydroimidazole (la), 2-mercapto-3,4,5,6-tetrahydropyrimidine (lb) and 2-mer-_capto-3,4,5,6-tetrahydro-7H-l,3-diazepine (1c) react with methyl iodide to give the corresponding mercaptomethyl derivatives (2a-2c). Reaction of these mercaptomethyl compounds with aminoacetaldehyde diethyl acetal followed by treatment with hydrochloric acid affords lH-2,3-dihydroimidazo[l,2-a]imidazole (4), 5,6,7,8-tetrahydroimidazo[l,2-a]pyrimidine (19) and 9H-5,6,7, 8-tetrahydroimidazo[l,2-a]-[l,3]-diazepine (22), respectively. These condensed imidazoles have been reacted with aromatic acid chlorides, isocyanates and isothiocyanates. The structure and anticonvulsant activity of these compounds are described.

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ID Code:93413
Deposited On:16 Jun 2012 09:26
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