Kumari, Nitee ; Vankar, Yashwant D. (2009) Synthesis and glycosidase-inhibitory activity of novel polyhydroxylated quinolizidines derived from D-glycals Organic and Biomolecular Chemistry, 7 (10). pp. 2104-2109. ISSN 1477-0520
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2009...
Related URL: http://dx.doi.org/10.1039/B900011A
Abstract
A number of structurally novel polyhydroxylated quinolizidines have been prepared starting from 2-deoxyglycosylamines which in turn were derived from D-glycals by following a methodology developed in our laboratory. In our strategy, Grignard reaction and ring-closing metathesis (RCM) reactions are the key steps to construct the desired skeletons. All synthesized final molecules were checked for glycosidase inhibition activity, and some were found to be selective for certain glycosidases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 93382 |
| Deposited On: | 16 Jun 2012 09:31 |
| Last Modified: | 16 Jun 2012 09:31 |
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