Regulation of glucosamine-6-phosphate deaminase synthesis in yeast

Singh, Balra j. ; Datta, Asis (1979) Regulation of glucosamine-6-phosphate deaminase synthesis in yeast Biochimica et Biophysica Acta: General Subjects, 583 (1). pp. 28-35. ISSN 0304-4165

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A basal level of glucosamine-6-phosphate deaminase is detected in yeast cells grown on glucose. However, a burst of enzyme production occurs in the presence of N-acetylglucosamine in pathogenic Candida albicans and non-pathogenic Saccharomyces cerevisiae. The enzyme synthesis stops and its concentration in the cells declines rapidly as soon as N-acetylglucosamine is removed from the medium. Experiments with RNA- and protein-synthesis inhibitors indicate that the appearance of new enzyme activity is dependent on concomitant new protein synthesis and the inducer operates at a transcriptional level. However, inhibition of DNA synthesis either by hydroxyurea or by mitomycin-C does not impair the synthesis of glucosamine-6-phosphate deaminase.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Glucosamine-6-phosphate Deaminase; Amino Sugar Metabolism; (Candida Albicans; Saccharomyces Cerevisiae)
ID Code:9334
Deposited On:02 Nov 2010 12:28
Last Modified:07 Feb 2011 10:53

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