Inhibitory effect of glucose and adenosine 3',5'-monophosphate on the synthesis of inducible N-acetylglucosamine catabolic enzymes in yeast

Singh, Balraj ; Guptaroy, Bipasha ; Hasan, Gaiti ; Datta, Asis (1980) Inhibitory effect of glucose and adenosine 3',5'-monophosphate on the synthesis of inducible N-acetylglucosamine catabolic enzymes in yeast Biochimica et Biophysica Acta: General Subjects, 632 (3). pp. 345-353. ISSN 0304-4165

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/030441...

Related URL: http://dx.doi.org/10.1016/0304-4165(80)90230-5

Abstract

Glucose can block the utilization of N-acetylglucosamine in Saccharomyces cerevisiae, a facultative aerobe, but not in Candida albicans, an obligatory aerobe. Furthermore, glucose represses the synthesis of the enzymes of the N-acetylglucosamine catabolic pathway in S. cerevisiae, but not in C. albicans. The results suggest that catabolite repression is present in S. cerevisiae, but not in C. albicans. Cyclic AMP added to S. cerevisiae cells maintained in a glucose medium cannot bring about their release from catabolite repression. On the contrary, the synthesis of inducible enzymes of N-acetylglucosamine pathway was inhibited by cyclic AMP in both the yeasts. This seems to indicate that cyclic AMP can penetrate into the yeast cells. Furthermore, cyclic AMP inhibits protein synthesis, suggesting that protein synthesis in yeast is under cyclic AMP control.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:N-acetylglucosamine Catabolism; Cyclic AMP; Glucose Inhibition; (Yeast)
ID Code:9331
Deposited On:02 Nov 2010 12:28
Last Modified:07 Feb 2011 10:42

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