Induction of N-Acetylmannosamine catabolic pathway in yeast

Biswas, Manika ; Singh, Balraj ; Datta, Asis (1979) Induction of N-Acetylmannosamine catabolic pathway in yeast Biochimica et Biophysica Acta: General Subjects, 585 (4). pp. 535-542. ISSN 0304-4165

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N-Acetylmannosamine kinase activity is absent from yeast cells grown on N-acetylmannosamine. However, other enzymes of the catabolic pathway, namely, N-acetylmannosamine-2-epimerase, N-acetylglucosamine kinase and glucosamine-6-phosphate deaminase are induced. In addition, a high affinity uptake system (permease) for the uptake of N-acetylglucosamine is synthesized under these conditions. The presence of either N-acetylmannosamine or N-acetylglucosamine as inducer is essential for the induced synthesis of these enzymes. The enzyme synthesis stops and their concentration in the cells declines rapidly as soon as inducer is removed from the medium. N-Acetyl-D-galactosamine can also induce all these enzymes except for N-acetylmannosamine-2-epimerase, suggesting the convergence of catabolic pathways for both the aminosugars at N-acetyl-D-glucosamine. Experiments with inhibitors of macromolecule synthesis suggest that the synthesis of RNA and protein is necessary for the induction of these enzymes whereas the synthesis of DNA is not.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:N-acetylmannosamine 2-epimerase Synthesis; Aminosugar Metabolism; (Yeast)
ID Code:9330
Deposited On:02 Nov 2010 12:28
Last Modified:07 Feb 2011 11:09

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