Damodharan, L. ; Pattabhi, Vasantha ; Nagarajan, K. (2004) Solvent interactions with β-Cyclodextrin as observed in crystal structures Molecular Crystals and Liquid Crystals, 423 (1). pp. 17-35. ISSN 1542-1406
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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1542140...
Related URL: http://dx.doi.org/10.1080/15421400490502328
Abstract
Nimesulide, an anti-inflammatory drug, was complexed with β cyclodextrin (βCD) in the presence of lysine in 10:10:1 molar ratio to increase its water solubility. The complexation did not take place in the crystal structure, but it exhibits two different crystal forms. The crystal structures show a difference in hydration pattern and conservation of the organic molecule 2,4 methyl pentane diol (MPD) binding site. Molecular mechanics studies carried out suggest a probable mode of binding of nimesulide with βCD.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Group. |
| Keywords: | β Cyclodextrin; Solvent Interactions with βCD; βCD Monomer Packing; Nimesulide β CD Complex; Hydration Pattern; Molecular Mechanics; Host-guest Interaction |
| ID Code: | 93202 |
| Deposited On: | 13 Jun 2012 10:34 |
| Last Modified: | 13 Jun 2012 10:34 |
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