Quino[8,1-bc][1,4]benzooxazepines- HIV-1 reverse transcriptase inhibitors

Nagarajan, K. (1997) Quino[8,1-bc][1,4]benzooxazepines- HIV-1 reverse transcriptase inhibitors Journal of the Indian Chemical Society, 74 . pp. 831-833. ISSN 0019-4522

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Abstract

A series of quinobenzoxazepinones showed activity against the reverse transcriptase of IIIV-1. The most potent one was 13 with an amino and methyl substitution. Active compounds 5,12 and 13 inhibited both AZT-sensiliveand AZT- resistant strains of HIV-1 but were inactive against 'pyridone-resistant' HIV-1 and HIV-2. The tricyclic drbenzoxazepine derivative 23 also showed activity against HIV-1 RT.

Item Type:Article
Source:Copyright of this article belongs to Indian Chemical Society.
ID Code:93197
Deposited On:13 Jun 2012 10:32
Last Modified:19 May 2016 06:20

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