Abnormalities in insulin secretion in healthy offspring of Indian patients with maturity-onset diabetes of the young

Mohan, V. ; Snehalatha, C. ; Ramachandran, A. ; Viswanathan, M. (1986) Abnormalities in insulin secretion in healthy offspring of Indian patients with maturity-onset diabetes of the young Diabetes Care, 9 (1). pp. 53-56. ISSN 0149-5992

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Official URL: http://care.diabetesjournals.org/content/9/1/53.fu...

Related URL: http://dx.doi.org/10.2337/diacare.9.1.53

Abstract

Serum C-peptide (CP) and immunoreactive insulin (IRI) responses were studied in 47 euglycemic offspring of patients with maturity-onset diabetes of the young (MODY). Mean IRI responses were not significantly different in nonobese offspring of MODY patients (O-MODY) but they were lower in obese O-MODY than in respective controls. Mean CP responses were low in both groups, the change being more pronounced in obese O-MODY. These findings indicate that alterations of secretion and metabolism of insulin can be detected even before glucose intolerance is seen in O-MODY.

Item Type:Article
Source:Copyright of this article belongs to American Diabetes Association.
ID Code:92443
Deposited On:01 Jun 2012 11:55
Last Modified:01 Jun 2012 11:55

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