Pancreatic beta cell function and peripheral activity of insulin in maturity onset diabetics - evaluation by mathematical applications

Abstract

Evaluation of the Pancreatic beta cell function and peripheral activity of insulin in diabetics were done using recently described mathematical formulae. Diabetics in general, had decreased beta cell function as well as impaired peripheral activity of insulin. In diabetics with ideal body weight, the chief defect was diminished insuling output which was directly proportional to the severity of diabetes. In obese diabetics, the main defect was at the periphery, and except in those with severe diabetes, beta cell function was better maintained. Application of these mathematical formulae helps in a clearer understanding of the kinetics of insulin and pathogenesis of diabetes in various types of diabetics.