Plasma glycoproteins in diabetes

Viswanathan, M. ; Snehalatha, C. ; Ramachandran, A. ; Mohan, V. (1981) Plasma glycoproteins in diabetes Journal of the Association of Physicians of India, 29 . pp. 711-713. ISSN 0004-5772

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Serum levels of glycoproteins-fibrinogen, α1, acid glycoprotein, α2macroglo-bulin, B2glycoprotein 1 and haptoglobin were estimated by immunodiffusion tech nique in three groups of subjects; (A) Non-diabetic controls (B) Newly detected diabetics and (C) diabetics with clinically manifest microangiopathy. Significant elevations in fibrinogen and haptoglobin were present in group B and C, the elevation being higher in group C. Levels of α1 acid GP and B1 GP 1 were significantly elevated only in group C. The concentration of α2 MG was higher in females compared to males and this variation was present in all three groups. Newly detected diabetics had lower concentration of α2 MG. There was no significant increase of this parameter in diabetics with microangiopathy. Thus enhanced synthesis of fibrinogen, haptoglobin, α1 acid glycoprotein and B2, giycoprotein-1, appear to be related to microvascular complication in diabetes while α2 macroglobulin does not appear to bear any relationship.

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Source:Copyright of this article belongs to Association of Physicians of India.
ID Code:92427
Deposited On:30 May 2012 13:48
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