Alzheimer's disease and the non-cholinergic activities of cholinesterases - a possible relationship

Abstract

Three of the major features of Alzheimer's disease are, a cholinergic deficit, amyloid beta peptide deposition in plaques and abnormalities in zinc status. A unified hypothesis linking these findings to the non-cholinergic activities of cholinesterases demonstrated by work in the author's laboratory is presented in this article.