Nagarajan, K. ; Talwalker, P. K. ; Nagangoud, A. ; Shah, R. K. ; Shenoy, S. J. (1989) Synthesis and oral hypoglycemic properties of two 4-oxo-4,5,6,7-tetrahydroindole-3-acetic acids Arzneimittel-Forschung /Drug Research, 39 (5). pp. 548-549. ISSN 0004-4172
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Abstract
Condensation of β -acetyl-2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexene-1-propionic acid(3) with n-butyl and isobutylamines affords the title acids 4 and 5, respectively, which show good oral hypoglycemic activity in normal rats. Acids 4 and 5, are also active in streptozocin-induced diabetic rats. Results of extensive pharmacological and acute toxicity tests are reported.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Editio Cantor Verlag (ECV). |
| ID Code: | 90764 |
| Deposited On: | 14 May 2012 04:44 |
| Last Modified: | 14 May 2012 04:44 |
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