Synthesis of [Imidazolidinone-2-14C]Go 10213 (satranidazole, cibemid

Anjaneyulu, B. ; Nagarajan, K. (1987) Synthesis of [Imidazolidinone-2-14C]Go 10213 (satranidazole, cibemid Journal of Labelled Compounds and Radiopharmaceuticals, 24 (4). pp. 423-430. ISSN 0362-4803

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For additional pharmacokinetic and metabolism studies in laboratory animals and in humans, Go 10213 was labelled with carbon-14 located on the carbonyl carbon atom of the ethyleneurea ring (Ring B) of the molecule. [imidazolidinone-2-14C]Go 10213 having a specific activity of 6.06 µCi/mg (1.75 mCi/mmol) was synthesised starting with [14C]ethyleneurea in two steps.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Synthesis; Go 10213; Ethyleneurea; carbon-14
ID Code:90761
Deposited On:14 May 2012 04:43
Last Modified:14 May 2012 04:43

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