Maller, R. K. ; Nagarajan, K. (1983) Synthesis of 14C-labelled 10-[3-(dimethylamino)-propyl]-2-nitrodibenz [b,f] [1,4] oxazepin-11-(10 H)-one (nitroxazepine)hydrochloride Journal of Labelled Compounds and Radiopharmaceuticals, 20 (12). pp. 1339-1348. ISSN 0362-4803
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jlcr.25...
Related URL: http://dx.doi.org/10.1002/jlcr.2580201205
Abstract
For pharmacokinetic and metabolism studies in animals and humans, nitroxazepine, an antidepressant, was labelled with carbon-14 at the 11-position of the dibenzoxazepine ring system in an overall yield of 12% starting with potassium [14C] cyanide. The labelled preparation had a specific activity of 0.95 µCi/mg. 14C Label was also introduced in the methyl group of the terminal nitrogen atom in the side chain of nitroxazepine, starting from its des-methyl derivative and using [14C] paraformaldehyde. In this case the overall yield of the final compound was 20%, and its specific activity 1.84 µCi/mg.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Synthesis; Nitroxazepine; 10-[3-dimethylamino)propyl]-2-nitrodibenz [b, f] [1,4] Oxazepin-11-(10 H)-one; Carbon-14; Antidepressant |
| ID Code: | 90751 |
| Deposited On: | 14 May 2012 04:32 |
| Last Modified: | 14 May 2012 04:32 |
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