Study of the target cell of the dengue virus-induced suppressor signal

Shukla, M. I. ; Chaturvedi, U. C. (1984) Study of the target cell of the dengue virus-induced suppressor signal British Journal of Experimental Pathology, 65 (2). pp. 267-273. ISSN 0007-1021

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Abstract

Dengue type 2 virus (DV) induces two generations of T suppressor cells (Ts1 and Ts2) in murine spleen. The Ts2 cells produce a soluble factor ( SF2 ) which suppresses DV-specific IgM antibody plaque-forming cells (PFC). In this study the target cell of SF2 was examined. The results show that SF2 requires a third generation of T cells (T3) in order to mediate suppression. The surface phenotype of this T3 cell is Ly 1+ and the suppression mediated is antigen specific.

Item Type:Article
Source:Copyright of this article belongs to Lewis, London.
ID Code:90662
Deposited On:11 May 2012 07:51
Last Modified:11 May 2012 07:51

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