Feighny, Robert J. ; Henry II, Berch E. ; Datta, Alok K. ; Pagano, Joseph S. (1980) Induction of DNA polymerase activity after superinfection of Raji cells with Epstein-Barr virus Virology, 107 (2). pp. 415-423. ISSN 0042-6822
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004268...
Related URL: http://dx.doi.org/10.1016/0042-6822(80)90308-6
Abstract
A new DNA polymerase (DNA nucleotidyl transferase) can be found in Raji cells following superinfeetion by Epstein-Barr virus (EBV). This polymerase is not present prior to infection and can be selectively extracted from infected cells. The polymerase is stimulated by ammonium sulfate. In vitro, the virus-specific drugs, phophonoacetic acid and acyclovirtriphosphate, inhibit the enzymatic activity. The enzyme can be distinguished from host enzymes by phosphocellulose chromatography. The characteristics of the enzyme extracted from virus-infected cells closely resemble those of the enzyme isolated from chemically induced virus-producing cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 9064 |
| Deposited On: | 29 Oct 2010 11:45 |
| Last Modified: | 30 May 2011 06:55 |
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