Alterations in iron levels in Japanese encephalitis virus infection

Mathur, A. ; Bharadwaj, M. ; Chaturvedi, U. C. (1990) Alterations in iron levels in Japanese encephalitis virus infection Journal of Experimental Pathology (Oxford, England), 71 (3). pp. 307-312. ISSN 0958-4625

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Abstract

Following Japanese encephalitis virus (JEV) infection in mice the serum iron concentration decreased; the decline started from day 3 and persisted up to day 9 postinfection. No significant difference was found in the total iron-binding capacity of serum in JEV-infected mice compared with that of controls. The hypoferraemia was associated with accumulation of iron in the spleen. Large amounts of stainable iron were demonstrated in splenic macrophages from day 5. This was accompanied by transient anaemia. Thus, the hypoferraemia, following intraperitoneal inoculation of JEV, was attributed to a block in the release of iron from the RES.

Item Type:Article
Source:Copyright of this article belongs to Blackwell Scientific Pub Ltd.
Keywords:Japanese Encephalitis Virus; Iron Metabolism; Host Defence
ID Code:90633
Deposited On:11 May 2012 07:25
Last Modified:25 Jun 2012 10:37

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