Viruria during acute Japanese encephalitis virus infection

Mathur, Asha ; Khanna, Nivedita ; Kulshreshtha, Rajesh ; Maitra, S. C. ; Chaturvedi, U. C. (1995) Viruria during acute Japanese encephalitis virus infection International Journal of Experimental Pathology, 76 . pp. 103-109. ISSN 0959-9673

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In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenous inoculation of MDF in mice resulted in leakage of cells, proteins and erythrocytes in the urine as a result of altered capillary permeability. The isolation of virus from kidney did not correlate with the shedding of virus in the urine. The histological examination of sections of kidneys showed no morphological damage; however, ultrastructural degenerative changes in the mesangial cells were observed following JEV infection. These data suggest that JEV-induced macrophage derived factor regulates the leakage of proteins, erythrocytes and cells into the urine.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Viruria; MDF; Albuminuria; Japanese Encephalitis Virus
ID Code:90530
Deposited On:10 May 2012 10:36
Last Modified:25 Jun 2012 10:43

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