Macrophage and dengue virus: friend or foe?

Chaturvedi, U. C. ; Nagar, Rachna ; Shrivastava, Richa (2006) Macrophage and dengue virus: friend or foe? Indian Journal of Medical Research, 124 . pp. 23-40. ISSN 0019-5340

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The cells of monocyte-macrophage (Mφ) lineage play important roles both in innate and adaptive immune responses. They are the first line of defence in body and their job is to phagocytose a foreign invader, the pathogen, digest it and remove it. Mφ help body in mounting the antigenspecific immune response by presenting the digested pathogen antigen in conjunction with major histocompatibility complex (MHC) class II molecules to recruit B and T lymphocytes response. Usually Mφ succeed in their job of eliminating most pathogens from the body but sometimes the pathogen strikes a "friendship" with them and starts using them for its benefit. A number of pathogens, including dengue virus (DV), subvert Mφ and use them for their replication, increasing the severity of damage to the body. This duality may be related to the fact that Mφ serve as efficient host cell for DV replication, in addition to being responsible for innate immunity and for initiating adaptive immune responses. This review gives a brief overview of the various roles of Mφ (enmity and friendship) during dengue virus infection.

Item Type:Article
Source:Copyright of this article belongs to Indian Council of Medical Research.
Keywords:Cytokines; Cytokine Receptors; Dendritic Cell; Dengue Virus; DHF; Langerhan's Cell; Kupffer's Cell; Macrophage; Pathogenesis; Signal Transmission
ID Code:90512
Deposited On:10 May 2012 10:38
Last Modified:19 May 2016 04:42

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