Cholinergic role in monkey Dorsolateral prefrontal cortex during bar press feeding behavior

Inoue, Masumi ; Oomura, Yutaka ; Nishino, H. ; Aou, Shuji ; Sikdar, Sujit Kumar ; Hynes, Mary ; Mizuno, Yuji ; Katabuchi, Toshihiko (1983) Cholinergic role in monkey Dorsolateral prefrontal cortex during bar press feeding behavior Brain Research, 278 (1-2). pp. 185-194. ISSN 0006-8993

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Cholinergic involvement in the neuronal activity of the dorsolateral (DL) prefrontal cortex in the monkey was investigated during bar-press feeding behavior. Iontophoretic application of ACh increased the firing rate of more than half of the cells through muscarinic receptors. Activity of ACh-sensitive cells did not correlate with any particular event during the feeding task. Continuous application of ACh markedly enhanced increases in response to events during the feeding task, and application of an ACh antagonist diminished response levels. This indicates that ACh release may occur during the feeding task and affect cortical cells to improve the signal-to-noise ratio of the excitatory input. Decreased responses to events during the feeding task diminished during ACh application. Driven discharges in the cells were evoked by stimulation of the basal nucleus of Meynert (BNM) where ACh containing cells are localized. This response was specifically blocked by iontophoretic application of atropine. In conclusion, cholinergic inputs arising from the BNM are distributed profusely among the cortical cells and modulate their excitability during bar-press feeding behavior.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Acetylcholine; Basal Nucleus of Meynert; Cholinergic Mechanism; Monkey; Prefrontal Cortex; Bar-press Feeding Behavior
ID Code:90205
Deposited On:07 May 2012 13:22
Last Modified:07 May 2012 13:22

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