cAMP directly facilitates Ca-induced exocytosis in bovine lactotrophs

Sikdar, Sujit K. ; Zorec, Robert ; Mason, William T. (1990) cAMP directly facilitates Ca-induced exocytosis in bovine lactotrophs FEBS Letters, 273 (1-2). pp. 150-154. ISSN 0014-5793

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We have used the whole cell patch clamp technique on single prolactin-secreting bovine lactotrophs to measure plasma membrane capacitance (Cm), an index of membrane surface area, under voltage-clamp during cytosol dialysis with Ca and cAMP. cAMP increased the magnitude and rate of Ca-induced exocytosis (Cm increase) without affecting membrane conductance; however, cAMP had no detectable effect on Cm when intracellular Ca was low. We thus report new evidence that cAMP can facilitate Ca-induced secretion in a synergistic fashion, by acting directly on the secretory apparatus, independently of membrane conductance activation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Calcium; Exocytosis; Cyclic AMP; Hormone; Secretion; Prolactin; Anterior Pituitary
ID Code:90202
Deposited On:07 May 2012 13:24
Last Modified:07 May 2012 13:24

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