α-chloralose opens the chloride channel of frog isolated sensory neurons

Ishizuka, S. ; Sikdar, S. K. ; Yasui, S. ; Oyama, Y. ; Akaike, N. (1989) α-chloralose opens the chloride channel of frog isolated sensory neurons Brain Research, 498 (1). pp. 181-184. ISSN 0006-8993

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0006-8993(89)90418-6

Abstract

The effect of α-chloralose on the sensory neurons isolated enzymatically and mechanically from frog dorsal root ganglia was studied using a suction-pipette technique. The threshold concentration of α-chloralose was around 3 x 10-5 M and the current produced by α-chloralose saturated at the concentration of 3 x 10-3 M or more. The dose-response curve for α-chloralose provided aKa value of 6 x 10-4M and a Hill coefficient of 1.8. The reversal potential of the response elicited by α-chloralose was close to the equilibrium potential for Cl- (ECl), indicating that the current was carried through Cl- channels. The current-voltage relationship indicated that there was little voltage dependence in the α-chloralose-induced response. The analysis of the variance of the α-chloralose-induced Cl- current fluctuations showed two types of the receptor-ionophore complexes with different channel conductances.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:α-chloralose; Chloride Channel; Frog; Sensory Neuron; Noise Analysis
ID Code:90201
Deposited On:07 May 2012 13:24
Last Modified:07 May 2012 13:24

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